Suggestions by @robertbarnes

Katharine Hepburn

as Aunt May in Spider-Man (1982)

Dennis Hopper

as Norman Osborn in Spider-Man (1982)

Kevin Bacon

as Harry Osborn in Spider-Man (1982)

Phoebe Cates

as Mary Jane Watson in Spider-Man (1982)

Diane Lane

as Mary Jane Watson in Spider-Man (1982)

Tom Hanks

as Peter Parker in Spider-Man (1982)

Ridley Scott

as Director in X-Men (1980)

John Vernon

as Senator Kelly in X-Men (1980)

Kathleen Turner

as Mystique in X-Men (1980)

Brad Dourif

as Toad in X-Men (1980)

Sven-Ole Thorsen

as Sabretooth in X-Men (1980)

Diane Lane

as Rogue in X-Men (1980)

Grace Jones

as Storm in X-Men (1980)

Michael Biehn

as Cyclops in X-Men (1980)

Susan Sarandon

as Jean Grey in X-Men (1980)

Paul Scofield

as Magneto in X-Men (1980)

Alec Guinness

as Xavier in X-Men (1980)

Kurt Russell

as Logan in X-Men (1980)

Patrick Wilson

as Norman Stansfield in Léon: The Professional (2014)

John Carpenter

as Director in Blade (1978)