This is when a female character lacks the usual immunity to slapstick that comes with her sex and is thus regularly on the receiving end of physical comedy in a manner normally reserved for male characters. She might regularly suffer Amusing Injuries, get Covered in Gunge, receive a Pie in the Face, get Panty Shot for Comedic Underwear Exposure, and have other slapstick tropes done to her. She is usually the Butt-Monkey or The Chew Toy of the show and what happens to the girl is Played for Laughs.
It is more rare to see women in these roles because of the Double Standard seen in things like Beauty Is Never Tarnished, Wouldn't Hit a Girl, or Double Standard: Abuse, Female on Male. Also, due to all of these things, the women who do fit this trope are more likely to be amusingly injured by other women, their own clumsiness, or events beyond anybody's control than by men. On occasions when a male does comically harm a female, it will almost invariably by accident, and the woman will often retaliate by doling out some slapstick right back at the male, considerably more painful or over-the-top than what happened to her. A male character deliberately harming a female character is far less likely to be played for laughs than the other way around.
With the passage of time, we both already have seen and will continue to see increasingly fewer restrictions on the use of this trope. Even being physically attractive does not guarantee immunity, since the Brainless Beauty is always an Acceptable Target. If the character is an Iron Butt Monkey, however, she'll tend to be a lot tougher if she's a woman than if she's a man. A woman who gets poked in the eye with a sharp stick will likely experience only a (temporary) loss of dignity; a man who gets poked in the eye with a sharp stick will have to wear an eyepatch. And it's still quite rare to see a female character comedically killed unless she's particularly repellent.
None of this is to suggest the men are getting away unscathed, by the way; if slapstick was only targeting the ladies then it would in fact know gender.
Exception: Instant Soprano always Knows Gender, except in blatant parodies of that trope.
Contrast is usually Immune to Slapstick.
