In 1979 he began as a disc jockey. In 1981 he began his TV career with the TV quiz Cijfers en Letters (Numbers and Letters, based on the French television programme). He began hosting TV shows like Superfan and Wereldwijs, but he especially became famous with Jeugdjournaal from the NOS. In 1989 he began hosting the original version of Lingo. In 1992 he went to Veronica, where he hosted the very successful All You Need is Love, which usually had more than 4 million viewers, which at the time was almost a third of the entire population. In 1998 he went to SBS 6, where he continued to host All You Need is Love. In 1999 he began hosting the very popular TV quiz Lotto Weekend Miljonairs. He was the host of Big Diet, where heavy people try to lose weight. When Lotto, the main sponsor of Weekend Miljonairs, decided to get the program to RTL 4, he almost lost his program. Because SBS 6 had stopped with All You Need is Love and didn't have another program for him to host, he signed a 3-year contract with RTL, where he continued to host Lotto Weekend Miljonairs. In 2008 the Lotto stopped sponsoring Weekend Miljonairs which resulted in the show stopping. Because of this, Ten Brink hosted the Dutch version of The Moment of Truth in the fall of 2008. He began hosting the entertainment programme Laat Ze Maar Lachen on RTL4, in April 2009. In November 2009, he began hosting the game show Succes Verzekerd, which was originally hosted by Carlo Boszhard. In 2019, he returned as the host of the revived show Lotto Weekend Miljonairs, which had become renamed into BankGiro Miljonairs (VriendenLoterij Miljonairs since 2021).
In 2021, he appeared as Sinterklaas in the film De Grote Sinterklaasfilm: Trammelant in Spanje.
In 2022, he appears in the film De Grote Sinterklaasfilm: Gespuis in de Speelgoedkluis
