A character completely misses a really obvious point for comic effect. The point is the sort of thing that any reasonable or informed person will spot and understand given a few seconds or enough information. However, the center of this trope is a person who, despite having all the time in the world and all the information, comes to a conclusion so wrong it's hard to be even further from correct. Occasionally, a character will even do it deliberately to be a smartass. Commonly elicits a response along the lines of "that's not what's wrong here". Visual gags are often involved. A Sister Trope to Dramatically Missing the Point.
Compare Alternative Joke Interpretation, Are You Pondering What I'm Pondering?, Bad News in a Good Way, Bait-and-Switch Comment, Cloudcuckoolander, The Ditz, Failed a Spot Check, Insane Troll Logic (logic that consists of comically missing the point), I Take Offense to That Last One, Mistaken for Profound, Need a Hand, or a Handjob?, Not Actually the Ultimate Question, Proportional Article Importance, Right for the Wrong Reasons, Sidetracked by the Analogy, and Skewed Priorities.
No Real Life Examples, Please! It would cost too much money to make another subpage.note The actual reason being that it's too common and attracts natter.