Fan CastingThe Powerpuff Girls Movie (2012)

Professor Utonium creates a mixture of sugar, spice, and everything nice in hope of producing the "perfect little girl" to improve Townsville, a city plagued by crime and injustice. He is shoved by his laboratory assistant, the destructive chimpanzee Jojo, causing him to accidentally break and spill a flask of Chemical X into the concoction, which explodes in Jojo's face. The experiment is successful, producing three little girls whom the Professor names Blossom, Bubbles, and Buttercup. He also discovers that the girls have gained superpowers from the added Chemical X. Despite the girls' recklessness with their powers, they all immediately grow to love each other as a family. The girls consider using the Antidote X to erase their powers, thinking they would be accepted as normal girls. The people of Townsville protest, apologizing for misjudging the girls and thanking them for their heroic deeds. At the insistence of the Mayor, the girls agree to use their powers to defend Townsville with the Professor's permission, becoming the city's beloved crime-fighting superhero team who are dubbed "the Powerpuff Girls".