Jennifer Tilly as Marie Payne / Mommy Long Legs: A large slender creature with an uncanny resemblance to a spider other than having only four limbs. Her hostile behavior towards staff members, which was recorded on camera back when the facility was in business, is revealed to have been because they experimented on her and turned her into the creature she is known to be. She is the film's main antagonist.
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Jennifer Tilly
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