Fan Casting Drew Barrymore as Karen Smith in Mean Girls (1994)

Drew Barrymore is known for her roles in Donnie Darko, 50 First Dates, and E.T. the Extra-Terrestrial. She has been suggested by fans for 1,527 roles on myCast, including Actresses. in The Most Attractive Celebrities. Similar actors include Reese Witherspoon, Amy Adams, and Kate Winslet. Drew Barrymore was suggested to play Karen Smith in Mean Girls (1994) by rebelwithautism. Other actors sugggested to play this role include Brittany Murphy. Mean Girls (1994) has 9 roles, including Cary Heron, Janis Ian, and Regina George.