Suggestions by @vikingwendigo

IShowSpeed

as IShowSpeed in Space Spam

Michael Douglas

as Guy-Am-I in Space Spam

Christopher Sabat

as Vegeta in Space Spam

Bill Fagerbakke

as Patrick Star in Space Spam

Keanu Reeves

as Shadow the Hedgehog in Space Spam

Kevin Afghani

as Waluigi and Wario in Space Spam

Chris Netherton

as Does Bad Things Guy in Space Spam

Shaquille O'Neal

as Shaquille O' Neal in Space Spam

Mephiles the Dark

as The antagonists in Space Spam

Does Bad Things Guy

as The antagonists in Space Spam

Tiff Crust

as The antagonists in Space Spam

Dennis the Hitman

as The antagonists in Space Spam

Double (Skullgirls)

as The antagonists in Space Spam

Emperor Zurg

as The antagonists in Space Spam

Cell (Dragon Ball)

as The antagonists in Space Spam

Dave Johnson (Childish Dad)

as The antagonists in Space Spam

Schnuffel Bunny

as The antagonists in Space Spam

Ace (Powerpuff Girls)

as The antagonists in Space Spam

Barney the Dinosaur

as The antagonists in Space Spam

Six Seven

as The antagonists in Space Spam