Suggestions by @thomasperez1

Zachary Quinto

as Quentin Beck in TASM Cinematic Universe

Score: +3

Aaron Taylor-Johnson

as Kraven the Hunter in Amazing Spider-Man (Uncasted Supporting Characters)

Score: -2

Jeff Goldblum

as Ezekiel Sims in Amazing Spider-Man (Uncasted Supporting Characters)

Score: +2

Zooey Deschanel

as Betty Brant in Amazing Spider-Man (Uncasted Supporting Characters)

Score: +3

Martyn Ford

as Thanos in Ultimate Marvel Cinematic Universe

Score: +4

Kit Harington

as Beetle in The Amazing Scarlet Spider

Score: +2

Gary Oldman

as Miles Warren in The Amazing Spider-Man Universe

Score: +2

Matthew Goode

as Theo in Madagascar 4

Score: +1

Tim Allen

as Calvo in Madagascar 4

Score: +1

Conrad Vernon

as Mason in Madagascar 4

Score: +1

Isabela Merced

as Jennifer in Madagascar 4

Score: +1

Sofia Carson

as Kaya in Madagascar 4

Score: +1

Morgan Dudley

as Ria in Madagascar 4

Score: +1

Sherri Shepherd

as Florrie in Madagascar 4

Score: +1

Samuel L. Jackson

as Zuba in Madagascar 4

Score: +1

Martin Short

as Stefano in Madagascar 4

Score: +1

Bryan Cranston

as Vitaly in Madagascar 4

Score: +1

Jessica Chastain

as Gia in Madagascar 4

Score: +1

Conrad Vernon

as Rico in Madagascar 4

Score: +1

Christopher Knights

as Private in Madagascar 4

Score: +1