Suggestions by @teokolar

Electro (Marvel)

as Best comic villain in The Best & Worst Of Villains

Sandman (Flint Marko)

as Best comic villain in The Best & Worst Of Villains

Leatherhead

as Best comic villain in The Best & Worst Of Villains

Tokka (TMNT)

as Best comic villain in The Best & Worst Of Villains

Venom (Character)

as Best comic villain in The Best & Worst Of Villains

Rahzar

as Best comic villain in The Best & Worst Of Villains

Hydro-Man

as Best comic villain in The Best & Worst Of Villains

Red Skull (Johann Schmidt)

as Best comic villain in The Best & Worst Of Villains

Magneto (X-Men Legends)

as Best comic villain in The Best & Worst Of Villains

Bebop

as Best comic villain in The Best & Worst Of Villains

Green Goblin (Lee & Ditko)

as Best comic villain in The Best & Worst Of Villains

Rocksteady

as Best comic villain in The Best & Worst Of Villains

Kingpin (Wilson Fisk)

as Best comic villain in The Best & Worst Of Villains

Baxter Stockman (TMNT)

as Best comic villain in The Best & Worst Of Villains

Doctor Octopus (Dr. Otto Octavius)

as Best comic villain in The Best & Worst Of Villains

The Joker

as Best comic villain in The Best & Worst Of Villains

Mutagen Man

as Best comic villain in The Best & Worst Of Villains

The Lizard

as Best comic villain in The Best & Worst Of Villains

Shredder

as Best comic villain in The Best & Worst Of Villains

Chameleon (Dmitri Smerdyakov)

as Best comic villain in The Best & Worst Of Villains