Suggestions by @superbat

Sean Astin

as Foogy Nelson in Spider-Man (Season 3) (2003-2004)

James Marsden

as Matt Murdock in Spider-Man (Season 3) (2003-2004)

Skeet Ulrich

as Herman Schultz in Spider-Man (Season 3) (2003-2004)

Diane Keaton

as Aunt May in Spider-Man (Season 3) (2003-2004)

John Goodman

as Wilson Fisk in Spider-Man (Season 3) (2003-2004)

Timothy Olyphant

as Mac Gargan in Spider-Man (Season 3) (2003-2004)

Kristin Kreuk

as Liz Allan in Spider-Man (Season 3) (2003-2004)

Freddie Prinze Jr.

as Flash Thompson in Spider-Man (Season 3) (2003-2004)

Michael Rosenbaum

as Max Dillon in Spider-Man (Season 3) (2003-2004)

Adrien Brody

as Quentin Beck in Spider-Man (Season 3) (2003-2004)

Ben Affleck

as Flint Marko in Spider-Man (Season 3) (2003-2004)

John Glover

as Miles Warren in Spider-Man (Season 3) (2003-2004)

Kirsten Dunst

as Gwen Stacy in Spider-Man (Season 3) (2003-2004)

Hayden Christensen

as Harry Osborn in Spider-Man (Season 3) (2003-2004)

Mark Hamill

as Otto Octavius in Spider-Man (Season 3) (2003-2004)

Kevin Bacon

as The Green Goblin in Spider-Man (Season 3) (2003-2004)

Hugh Laurie

as Dr. Curt Connors in Spider-Man (Season 3) (2003-2004)

Mary Elizabeth Winstead

as Mary Jane Watson in Spider-Man (Season 3) (2003-2004)

Joseph Gordon-Levitt

as Peter Parker in Spider-Man (Season 3) (2003-2004)

Spoiler

as The Green Goblin in Spider-Man (Season 3) (2003-2004)