Suggestions by @phantomdesperado

Brion James

as Kingpin in The Amazing Spider-Man (Franchise)

Christopher Lloyd

as Scorpion in The Amazing Spider-Man (Franchise)

Rob Lowe

as Ned Leeds in The Amazing Spider-Man (Franchise)

Brion James

as Kraven in The Amazing Spider-Man (Franchise)

Robin Williams

as Mysterio in The Amazing Spider-Man (Franchise)

Michael Biehn

as Electro in The Amazing Spider-Man (Franchise)

Michael Madsen

as Sandman in The Amazing Spider-Man (Franchise)

Alan Rickman

as Chameleon in The Amazing Spider-Man (Franchise)

Ben Kingsley

as Vulture in The Amazing Spider-Man (Franchise)

William Shatner

as Ben Parker in The Amazing Spider-Man (Franchise)

Brad Dourif

as Carnage in The Amazing Spider-Man (Franchise)

Val Kilmer

as Venom in The Amazing Spider-Man (Franchise)

Halle Berry

as Black Cat in The Amazing Spider-Man (Franchise)

Bob Hoskins

as Doctor Octopus in The Amazing Spider-Man (Franchise)

Elisabeth Shue

as Liz Allan in The Amazing Spider-Man (Franchise)

Chris Penn

as Flash Thompson in The Amazing Spider-Man (Franchise)

Al Pacino

as The Big Man in The Amazing Spider-Man (Franchise)

Courteney Cox

as Betty Brant in The Amazing Spider-Man (Franchise)

Richard Roundtree

as Robbie Robertson in The Amazing Spider-Man (Franchise)

Ellen Burstyn

as May Parker in The Amazing Spider-Man (Franchise)