Suggestions by @noahpopejoy

Zendaya

as Alex in A New Recruit: Totally Spies Fan Film Dream Casting

Zooey Deschanel

as Jean DeWolff in Ultimate Spider-Man

Zooey Deschanel

as Jean DeWolff in Ultimate Spider-Man 2

J.K. Simmons

as J. Jonah Jameson in Ultimate Spider-Man 2

Mekhi Phifer

as Robbie Robertson in Ultimate Spider-Man 2

Dave Annable

as Eddie Brock in Ultimate Spider-Man 2

Michael Johnston

as Harry Osborn in Ultimate Spider-Man 2

Julie Andrews

as Aunt May in Ultimate Spider-Man 2

Colin Firth

as Norman Osborn in Ultimate Spider-Man 2

Javier Bardem

as Doctor Octopus in Ultimate Spider-Man 2

Amy Acker

as Betty Brant in Ultimate Spider-Man 2

John Cena

as Hammerhead in Ultimate Spider-Man 2

Dwayne Johnson

as Tombstone in Ultimate Spider-Man 2

Dove Cameron

as Gwen Stacy in Ultimate Spider-Man 2

Madeline Petsch

as Mary Jane Watson in Ultimate Spider-Man 2

Amy Acker

as Betty Brant in Ultimate Spider-Man

Dave Annable

as Eddie Brock in Ultimate Spider-Man

Mekhi Phifer

as Robbie Robertson in Ultimate Spider-Man

Terrence Howard

as The Prowler in Ultimate Spider-Man

Javier Bardem

as Dr. Otto Octavius in Ultimate Spider-Man