Suggestions by @mask01

Orlando Bloom

as Tewkesbury in Enola Holmes (1997)

Maggie Smith

as Eudoria Holmes in Enola Holmes (1997)

Gary Oldman

as Mycroft Holmes in Enola Holmes (1997)

Bill Murray

as Ray Embrey, a corporate public relations in Hancock (1988)

Meryl Streep

as Mary Embrey, Ray's wife and Hancock's ex-wife in Hancock (1988)

Billy Dee Williams

as John Hancock, an alcoholic superhero. in Hancock (1988)

Danny Glover

as John Hancock, an alcoholic superhero. in Hancock (1988)

Angela Bassett

as Ramonda in Black Panther

Daniel Kaluuya

as W'kabi in Black Panther

Danai Gurira

as Okoye in Black Panther

John C. Reilly

as Uncle Ben in The Advantage Of The Marvelous Spidermqn

Jensen Ackles

as The Thing in Fantastic Four

Dylan Minnette

as Spider-Man in The Advantage Of The Marvelous Spidermqn

Maya Hawke

as Mary Jane Watson in The Advantage Of The Marvelous Spidermqn

Winona Ryder

as Young Roxy Simpson [Mid 20s] in The Ghost Rider {Starring Keanu Reeves}

Keanu Reeves

as Young Johnny Blaze [Mid 20s] in The Ghost Rider {Starring Keanu Reeves}

Eiza González

as Alejandra Jones in The Ghost Rider {Starring Keanu Reeves}

Michelle Rodriguez

as Alejandra Jones in The Ghost Rider {Starring Keanu Reeves}

Jensen Ackles

as The Thing in MCU The fantastic four

Billy Bob Thornton

as Carter Slade in The Ghost Rider {Starring Keanu Reeves}