Suggestions by @castingsinmyblood
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Thomas O'Malley
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Crimson Dynamo
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Jake Gittes
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Ulysses S. Grant
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Royce (Predators)
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Lord Moritsugu Katsumoto
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Khan Noonien Singh
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Lex Luthor
as Miguel Ferrer in What if this actor played

The Punisher (Frank Castle)
as Stephen Lang in What if this actor played

Bilbo Baggins
as David Tomlinson in What if this actor played

General Sam Lane
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Conquest (Invincible)
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Grendel's Mother
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Gillian B. Loeb (Batman)
as Paul Giamatti in What if this actor played

Samyaza (Noah (2014))
as Candy Candido in What if this actor played

Puppet Master (Marvel)
as Brad Dourif in What if this actor played

Victor Frankenstein
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Silas Stone
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Uncle Chuck
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Mongul
as Joel Edgerton in What if this actor played