Suggestions by @aidanmanley

Lance Bangs

as Otto Octavius/Dr Octopus in Spiderman

Cooper Barnes

as Dr Curt Connor/Lizard in Spiderman

Laurie Metcalf

as Aunt May Parker in Spiderman

Willem Dafoe

as Green Goblin in Marvel Cinematic Universe

Robert Downey Jr.

as Doctor Doom in Marvel Cinematic Universe

Ebon Moss-Bachrach

as The Thing in Marvel Cinematic Universe

Mila Kunis

as Black Cat in Marvel Cinematic Universe

Rachel Brosnahan

as Black Cat in Marvel Cinematic Universe

Vanessa Kirby

as The Invisible Woman in Marvel Cinematic Universe

Isabel May

as Spider-Gwen in Marvel Cinematic Universe

Joseph Quinn

as The Human Torch in Marvel Cinematic Universe

Hugh Jackman

as Wolverine in Marvel Cinematic Universe

Jim Parsons

as Riddler in Casting James Gunn's DCU! :D

Ebon Moss-Bachrach

as Reverse flash in Dcu's James Gunn

Sean Gunn

as Maxwell Lord in Dcu's James Gunn

Skyler Gisondo

as Jimmy Olsen in Dcu's James Gunn

Chris Pratt

as Hal Jordan in Dcu's James Gunn

Cooper Barnes

as Batman in Dcu's James Gunn

Chris Pratt

as Hal Jordan in Casting James Gunn's DCU! :D

Adria Arjona

as Diana Price (Wonder Woman) in All Superheroes and Villains (DC, Marvel, & Dark Horse Comics)