Suggestions by @adamatc

David Strathairn

as John Milton in The Devil's Advocate (2017)

Sigourney Weaver

as Waverly in Gender-Swapped : The Man from U.N.C.L.E.

Gina Carano

as Solo in Gender-Swapped : The Man from U.N.C.L.E.

Olga Kurylenko

as Illya in Gender-Swapped : The Man from U.N.C.L.E.

Alan Alda

as Victor Ziegler in Eyes Wide Shut (1989)

Mia Farrow

as Alice Harford in Eyes Wide Shut (1989)

Woody Allen

as Dr. William "Bill" Harford in Eyes Wide Shut (1989)

Johnny Galecki

as Harold Lloyd in Actor Biopics

Johnny Galecki

as Harold Lloyd in Buster Keaton: The Great Stone Face.

Johnny Galecki

as Harold Lloyd in Whispers of Silence

Oliver Reed

as Alfred Borden / Bernard Fallon in The Prestige (1976)

Brian Dennehy

as Colonel William "Hawk" Hawkins, USAF (Ret.) in Space Cowboys (1980)

Burt Lancaster

as Colonel Francis D. "Frank" Corvin, Ph.D., USAF (Ret.) in Space Cowboys (1980)

Lee Marvin

as Colonel Francis D. "Frank" Corvin, Ph.D., USAF (Ret.) in Space Cowboys (1980)

George C. Scott

as Captain the Reverend "Tank" Sullivan, USAF (Ret.) in Space Cowboys (1980)

Walter Matthau

as Captain Jerry O'Neill, USAF (Ret.) in Space Cowboys (1980)

Charlton Heston

as Colonel Francis D. "Frank" Corvin, Ph.D., USAF (Ret.) in Space Cowboys (1980)

Mel Gibson

as Lucas "Luke" Jackson in Cool Hand Luke (1992)

Aubrey Plaza

as Bridget Gregory in The Last Seduction (2024)

Mathieu Kassovitz

as Claude Lacombe in Close Encounters of the Third Kind (2007)