Suggestions by @TheCreditableKudos

Jim Carrey

as Cletus Kasady in Spider-Man 4 (2027)

Gosha Kutsenko

as Aleksei Sytsevich/Rhino in Spider-Man 4 (2027)

Blair Underwood

as Hobie Brown/Prowler in Spider-Man 4 (2027)

Patrick Warburton

as Wilbur Day/Stilt-Man in Spider-Man 4 (2027)

Rachel McAdams

as Felicia Hardy/Black Cat in Spider-Man 4 (2027)

Mckenna Grace

as Mayday Parker in Spider-Man 4 (2027)

David Corenswet

as Billy Connors in Spider-Man 4 (2027)

Judith Hoag

as Martha Connors in Spider-Man 4 (2027)

Doug Jones

as Dmitry Smerdyakov/Dmitry Kravinoff/Chameleon in Spider-Man 4 (2027)

Bruce Campbell

as Quentin Beck/Mysterio in Spider-Man 4 (2027)

Brad Pitt

as Sergei Kravinoff/Kraven The Hunter in Spider-Man 4 (2027)

Brad Pitt

as Sergei Kravinoff/Kraven The Hunter in Spider-Man 4 (2027)

Aaron Taylor-Johnson

as Sergei Kravinoff/Kraven The Hunter in Spider-Man 4 (2027)

Jared Leto

as Michael Morbius/Morbius The Living Vampire in Spider-Man 4 (2027)

Ben Stiller

as Herman Schultz/Shocker in Spider-Man 4 (2027)

Dylan Baker

as Dr. Curt Connors/Lizard in Spider-Man 4 (2027)

Ted Raimi

as Hoffman in Spider-Man 4 (2027)

Elizabeth Banks

as Betty Brant in Spider-Man 4 (2027)

J.K. Simmons

as J. Jonah Jameson in Spider-Man 4 (2027)

James Cromwell

as Captain George Stacy in Spider-Man 4 (2027)