Perhaps intended to be a feminine form of Samuel, using the name suffix antha (possibly inspired by Greek ἄνθος (anthos) meaning "flower"). It originated in America in the 18th century but was fairly uncommon until 1964, when it was popularized by the main character on the television show Bewitched.
Sam Puckett
Sam Manson
Sam Sparks
Sam (Totally Spies!)
Samantha "Sam" Button
Samantha LaRusso
Atom Eve (Samantha Eve Wilkins)
Samantha "Sam" Giddings
Samantha "Sam" Baker
Sam Sharp
Samantha Jackson (Ted)
Samantha Parkington
Samantha "Sam" Montgomery
Samantha Stephens
Samantha Jones
Samantha Fraser
Samantha Traynor
Samantha Lang
Samantha Nishimura
Samey/Sammy (Total Drama)
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