Extended social isolation that makes a person go crazy. People who are stranded alone will usually be subject to this. A person on a ship or in space where it is months or years until they reach their destination are also at risk. Solitary confinement can be a way of invoking this as punishment.
Fan Casting
Indominus Rex
Spinel
Charles Muntz
Chuck Noland
Dr. Ivo Robotnik
Gollum
Demona
He Who Remains (Marvel Cinematic Universe)
Ego (Marvel Cinematic Universe)
Veruca Dumont
Edmond Dantès
Patricia Tannis
Daniel Noyer
Fiona Fox
Laughing Jack
Extra Life
Wei Ying (魏婴, Wèi Yīng) / Wei Wuxian (魏无羡, Wèi Wúxiàn) (from The Untamed/Grandmaster of Demonic Cultivation: Mo Dao Zu Shi)
Buck (Ice Age)
Robert Neville
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