Adaptations change things. Otherwise, what's the point? There's a whole index of 'em. Adaptational Gender Identity is when a character's gender alignment changes — cisgender to transgender, transgender to cisgender, either to nonbinary, etc. This will often come from the creator's own experiences if the actor playing the character or the writer writing the character are trans. Sometimes it's a Trans Audience Interpretation that was made canon, or a character with an Ambiguous Gender or Ambiguous Gender Identity being explicitly made something. Subtrope to Adaptational Diversity. Compare to Adaptational Sexuality for changes to sexual orientation.
Fan Casting
Frankie Stein
Halo (Young Justice)
Frank-N-Furter
Anybodys
Gren (Cowboy Bebop)
Double Trouble/Flutterina
Jewelstar
Perfuma
Leatherhead (TMNT: Mutant Mayhem)
Unique Adams
Gwen Stacy (Spider-Verse)
Desire of The Endless
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