The first season focuses on the Kappa Kappa Tau sorority at Wallace University, led by Chanel Oberlin and her fellow Chanels #2, #3, and #5, that is threatened by Dean Cathy Munsch. Events reignite a 20-year-old murder mystery, with the reemergence of the serial killer dressed as the Red Devil mascot, who begins targeting the sorority members.
The second season shows Cathy Munsch having opened a hospital after leaving the university business. She has taken an acquitted Chanel, Libby, and Sadie under her wing after the real Red Devil killer came clean. While handling different medical cases, Cathy and the Chanels end up encountering a new serial killer called the Green Meanie.
