A few months after the events of Saints Row: The Third, The Boss, Shaundi and Pierce Washington are called upon to assist MI-6 agent Asha Odekar and former Deckers leader Matt Miller in infiltrating a Middle Eastern compound to assassinate former STAG leader Cyrus Temple and prevent a nuclear missile strike against Washington D.C. The Boss kills Cyrus but is unable to stop him from launching the missile. The Boss climbs aboard the nuke and disarms it before it reaches Washington, earning the adoration of America.
Five years later, the Boss has been elected President of the United States, with the other members of the Saints, Keith David and former Vice Kings leader Benjamin King acting as their cabinet. While preparing for a press conference, the Boss is told that Asha and Matt have arrived at the White House to warn them of what they suspect is an impending alien invasion. Just as the Boss is informed, the invasion begins spearheaded by the alien warlord Zinyak, who captures the entire cabinet including the Boss.
