The series is set on a gigantic, mysterious and seemingly endless train traveling through a barren landscape, whose cars contain a variety of bizarre, fantastical and impossible environments. Passengers on the train complete challenges as they proceed from car to car which help them resolve their psychological trauma and emotional issues. Every season of Infinity Train (referred to as a "Book", each with its own separate subtitle) follows its own storyline and set of characters, although they are all set in the same universe and some characters appear across different seasons. All four seasons of Infinity Train have received critical acclaim for their complex themes and characters, writing, uniqueness, visual animation style, and voice acting. In August 2020, Dennis stated that, although he wanted to continue the series for a total of eight seasons, most of the crew had been laid off and the series was at risk of not being renewed for a fifth season; Dennis suggested that HBO Max might be concerned that the series' stories and themes were too dark and unappealing to children. Promotional material for the fourth season refer to it as the final season of Infinity Train. #RenewInfinityTrain
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