After the events of Spider-Man: No Way Home, Peter Parker/Spider-Man graduated and entered college, it's seen that the hero is more experienced and mature than before. Then the Lizard appears, in which he is on a murder spree before Spider-Man tries to stop him. The Lizard poisons Spider-Man and throws him out of a building. It is later revealed that Calypso is hypnotizing the Lizard to place his order. Spider-Man defeats Calypso and the Lizard, but Spider-Man believes that the Lizard died due to Calypso's effect on his brain. The film story is inspired by the comic book arc "Torment" by Todd McFarlane
Russo Brothers
Tom Holkenborg
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