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Kaine Parker/Scarlet Spider is Peter' long lost older brother. Before Peter was born, Kaine ran away from home because he could not stand his parents working all the time. During his travels, he collapsed in the Phoenix, Arizona Desert where a poisonous spider bit him.

A passing motorist, Dr. Jonathan Drew, saved Kaine's life and looked after him with his wife, Miriam. Kaine then was given spider powers and used them to fight crime as the Scarlet Spider. He promised to help the Drew's find their missing daughter Jessica and hopefully, keep Peter out of Eddie Brock/Venom's warpath.

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