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A college student and the daughter of George and Helen Stacy, Gwen was the first romantic interest for Peter following his high school graduation before she was murdered by the Green Goblin (Norman Osborn). Her death has haunted Peter ever since, and stories published long afterwards indicate she still holds a special place in his heart. She was initially cold towards Peter. Gradually, however, a romance develops because Gwen, a science major, seems to appreciate Peter's intellectual personality. Their relationship begins almost immediately after Peter stops going out with Mary Jane, whom he starts seeing as shallow and self-absorbed.

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